{"product_id":"choline-bitartrate-100-capsules-pure-encapsulations","title":"Choline (Bitartrate) - 100 Capsules | Pure Encapsulations","description":"\u003ch4 class=\"\"\u003eKey vitamin to support healthy methylation, cell function and neurotransmission‡\u003c\/h4\u003e\u003cp class=\"\"\u003eWhile long considered a non-essential vitamin, recent evidence confirms that the body cannot synthesize enough choline to meet daily needs. This has prompted the National Academy of Science to create a daily value for choline of 550 mg. Dietary intake of choline is often below this level. \u003c\/p\u003e\u003cp class=\"\"\u003eCholine is an important nutrient for methylation, cell membrane structure and neurotransmission, and lipid metabolism and transport. Choline and its metabolites are the major source of methyl groups in the diet. Methylation plays many roles including neurotransmission, vitamin assimilation, DNA synthesis and gene regulation. \u003c\/p\u003e\u003cp class=\"\"\u003eCholine is required for the synthesis of phospholipids and acetylcholine, a neurotransmitter involved in attention, learning and memory. Certain genetic variations in MTHFD1 and PEMT, enzymes that play critical roles in methylation and phosphatidylcholine synthesis, respectively, have been associated with increased dietarycholine needs. \u003c\/p\u003e\u003cp class=\"\"\u003eSince the de novo synthesis of phosphatidylcholine requires the estrogen-inducible PEMT enzyme, women with low estrogen levels and\/or certain SNPs in the PEMT gene have increased choline needs. Postmenopausal women with lower estrogen have higher dietary choline requirements because of reduced PEMT function. Choline requirements also increase during pregnancy. One clinical trial showed that women who consumed 480 mg of choline daily during pregnancy had offspring with faster processing speed than those who did not. \u003c\/p\u003e\u003cp class=\"\"\u003eA randomized, double blind, placebo-controlled trial suggests that higher intakes of choline also promote healthy hepatic fat metabolism.‡\u003cbr\u003e\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":51663099593082,"sku":"PUR_0191","price":20.66,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0880\/0092\/1883\/files\/PUR_0191-Choline-Bitartrate_0c991af9-9c90-4600-9170-ab49725d0219.jpg?v=1764738930","url":"https:\/\/amritasync.co.uk\/products\/choline-bitartrate-100-capsules-pure-encapsulations","provider":"Amrita Sync","version":"1.0","type":"link"}